About RADICALS     

RADICALS is a large clinical trial which is taking place in the UK, Canada, Denmark and the Republic of Ireland at the moment.

It is a phase III randomised controlled trial that will recruit approximately 3000 men to help answer two important questions for men who have had surgery for prostate cancer:

  • Which is the best way to use radiotherapy after surgery?
  • Which is the best way to use hormone treatment with any radiotherapy given after surgery 

In breast cancer, surgery is followed by radiotherapy and hormone treatment, because the combination is better than surgery alone.  In prostate cancer, surgery alone is a standard treatment, and we are not sure how best to use radiotherapy and hormone treatment after surgery.

The trial may be suitable at some point for most men who have a radical prostatectomy.

pointerRead more about RADICALS


22nd May 2014

We are pleased to say that we will continue recruting to both comparisons in RADICALS-HD until mid-2015 and possibly longer for RADICALS-RT (MID-2016).

Also, everyone should now have all the documents for the recently approved protocol amendment version 5.0

8th November 2013

Princess Margaret Hospital in Toronto put in their 100th patient on 30th October 2013! Well done and congratulations for all your hard work! They now join Guy’s Hospital and Mount Vernon Hospital in London as the centres with more than 100 patients. We look forward to seeing this list grow.

15th July 2013

We have reached a fantastic milestone in RADICALS-HD where we now have 1000 patients in each of the two RADICALS-HD comparisons (none vs short and short vs long). Our target accrual is at least 1370 patients in the none-vs-short comparison and at least 1130 patients in the short-vs-long comparison. Currently we have 1916 patients in RADICALS-HD overall and we are hoping to recruit an overall total in excess of 2500 patients, so, we still need everyone to keep up the great work and keep recruiting patients.

11th March 2013

Claire Murphy who has been the RADICALS Trial Manager at the MRC CTU since the trial started will no longer be working on the trial. We wish her all the best and will greatly miss her. Dipa Noor will be replacing Claire and can be contacted at dno@ctu.mrc.ac.uk  


Latest Updates


February 2015


1st Canadian centre to recruit 100 patients!


YouTube Video: Hormone Duration Randomisation - Q&A Section Part 1

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