RADICALS is a large clinical trial which is taking place in the UK, Canada, Denmark and the Republic of Ireland.

It is a phase III randomised controlled trial that recruited nearly 4000 men from 149 centres over 9 years. This makes it the largest trial to be conducted on this population group. RADICALS will help to answer two important questions for men who have had surgery for prostate cancer:

  • Which is the best way to use radiotherapy after surgery?
  • Which is the best way to use hormone treatment with any radiotherapy given after surgery?

In breast cancer, surgery is followed by radiotherapy and hormone treatment, because the combination is better than surgery alone. In prostate cancer, surgery alone is a standard treatment, and we are not sure how best to use radiotherapy and hormone treatment after surgery.


Latest News

We are delighted to inform you that RADICALS closed to recruitment on 30th December 2016. The trial randomised 2840 patients to RADICALS-HD and 1396 patients to RADICALS-RT. This is a huge achievement and we would like to say thank you to all the patients who participated in the trial and the trial teams at our recruiting centres.


How to enter patients


Recruitment rates to date


Website for Canadian participants