RADICALS is a large clinical trial which is taking place in the UK, Canada, Denmark and the Republic of Ireland at the moment.

It is a phase III randomised controlled trial that will recruit approximately 3000 men to help answer two important questions for men who have had surgery for prostate cancer:

  • Which is the best way to use radiotherapy after surgery?
  • Which is the best way to use hormone treatment with any radiotherapy given after surgery?

In breast cancer, surgery is followed by radiotherapy and hormone treatment, because the combination is better than surgery alone. In prostate cancer, surgery alone is a standard treatment, and we are not sure how best to use radiotherapy and hormone treatment after surgery.

The trial may be suitable at some point for most men who have a radical prostatectomy.

pointerRead more about RADICALS


11th January 2017

We are delighted to inform you that RADICALS closed to recruitment on 30th December 2016. The trial randomised 2840 patients to RADICALS-HD and 1396 patients to RADICALS-RT. This is a huge achievement and we would like to say thank you to all the patients who participated in the trial and the trial teams at our recruiting centres.

25th October 2016

We are delighted to announce that RADICALS will be closing to recruitment on 30th December 2016! Thank you to everyone who has helped us throughout these years and enabling us to recruit >4000 patients!

I would also like to welcome Katherine Beaney as the RADICALS Data Manager at the MRC CTU.

24th March 2016

We have some exciting and important updates which you can read about in the latest version of the RADICALS Newsletter. We hope you take a look and please feel free to get in touch if you have any comments or questions.

1st July 2015

RADICALS-HD closed on 30th June 2015 with just under 3000 patients!
RADICALS-RT is still open to recruitment so please continue to support us.

22nd May 2014

We are pleased to say that we will continue recruting to both comparisons in RADICALS-HD until mid-2015 and possibly longer for RADICALS-RT (mid-2016).

Also, everyone should now have all the documents for the recently approved protocol amendment version 5.0

8th November 2013

Princess Margaret Hospital in Toronto put in their 100th patient on 30th October 2013! Well done and congratulations for all your hard work! They now join Guy’s Hospital and Mount Vernon Hospital in London as the centres with more than 100 patients. We look forward to seeing this list grow.

15th July 2013

We have reached a fantastic milestone in RADICALS-HD where we now have 1000 patients in each of the two RADICALS-HD comparisons (none vs short and short vs long). Our target accrual is at least 1370 patients in the none-vs-short comparison and at least 1130 patients in the short-vs-long comparison. Currently we have 1916 patients in RADICALS-HD overall and we are hoping to recruit an overall total in excess of 2500 patients, so, we still need everyone to keep up the great work and keep recruiting patients.

Latest Updates


December 2016


RADICALS completed recruitment on 30th December 2016!


YouTube Video: Hormone Duration Randomisation - Q&A Section Part 1

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