RADICALS is a large clinical trial which is taking place in the UK, Canada, Denmark and the Republic of Ireland.

It is a phase III randomised controlled trial that recruited nearly 4000 men from 149 centres over 9 years. This makes it the largest trial to be conducted on this population group. RADICALS will help to answer two important questions for men who have had surgery for prostate cancer:

  • Which is the best way to use radiotherapy after surgery?
  • Which is the best way to use hormone treatment with any radiotherapy given after surgery?

In breast cancer, surgery is followed by radiotherapy and hormone treatment, because the combination is better than surgery alone. In prostate cancer, surgery alone is a standard treatment, and we are not sure how best to use radiotherapy and hormone treatment after surgery.


Latest News

January 2019

RADICALS Protocol v6.0 Substantial Amendment is ready for site processing. Please navigate to the Members Area for documentation and email the Amendment Acknowledgement, ISF Assessment Checklist and Local R&D approval to mrcctu-add-aspirin@ucl.ac.uk


How to enter patients


Recruitment rates to date


Website for Canadian participants