RADICALS-RT monthly accrual report (Dec-2016)

Radiotherapy Timing Randomisation


Summary points

  • 30 patients recruited to Radiotherapy Timing question this month
  • 1396 patients recruited to Radiotherapy Timing question in total
  • 1250 patients aiming to be recruited by mid-2016

Radiotherapy Timing detail

The first patient was randomised on 22-Nov-2007

The total number of patients randomised to RT timing randomisation for the month ending 31-Dec-2016 is: 1396 patients out of a target of 1250 patients


Table 1 - RADICALS-RT allocated treatment

Variable Summary statistics
Allocated treatment - RADICALS-RT 1 Early RT 699 (50%)
Deferred RT 697 (50%)
1: n (column percentage) 

Table 2 - Randomising country

Variable Summary statistics
Country 1 UK 1148 (82%)
Canada 49 (4%)
Ireland 12 (1%)
Denmark 187 (13%)
1: n (column percentage) 

Figure 1 - Monthly randomisations by country for the last 13 months

Figure 1


Figure 2 - Observed and projected RT timing randomisation - Full period

Figure 2


Table 3 - Radiotherapy Timing randomisation for the last three months

Rank Hospital Country First Recent Oct Nov Dec Total
1 Rigshospitalet Uni Hosp Denmark 2011_08 2016_12 . . 3 93
2 Herlev University Hospital Denmark 2011_10 2016_09 . . . 71
3 Leeds, St James Uni Hosp UK 2008_07 2016_12 1 1 1 49
4 Wakefield, Pinderfields Gen Hosp UK 2009_01 2016_10 3 . . 49
5 Kent And Canterbury Hosp UK 2009_07 2016_12 . 2 1 39
6 Bradford Royal Inf UK 2009_02 2016_12 1 2 2 38
7 Bristol, Southmead Hosp UK 2009_01 2016_12 . . 1 38
8 Southampton General Hosp UK 2010_04 2016_09 . . . 37
9 Birmingham Heartlands Hosp UK 2010_03 2016_12 . 1 1 36
10 Birmingham, Queen Elizabeth Hosp UK 2011_04 2016_12 1 . 1 35
11 Wolverhampton, New Cross Hosp UK 2013_04 2016_12 . 1 5 33
12 Hull, Castle Hill Hosp UK 2009_11 2016_12 1 . 1 29
13 Newport, Royal Gwent Hosp UK 2008_09 2016_10 1 . . 29
14 Herts, Mount Vernon Hosp UK 2008_02 2015_11 . . . 26
15 York District Hosp UK 2008_12 2016_12 . 1 1 24
16 Romford, Queen's Hosp UK 2011_01 2016_07 . . . 23
17 Maidstone Hospital UK 2009_06 2016_10 1 . . 22
18 London, Guy's Hosp UK 2009_08 2016_04 . . . 21
19 Surrey, Royal Surrey County Hosp UK 2009_01 2016_11 . 1 . 20
20 Royal Devon and Exeter Hosp UK 2010_11 2016_08 . . . 20
21 Belfast City Hosp UK 2009_11 2016_01 . . . 20
22 Coventry, Uni Hosp Coventry & Warwicks UK 2008_12 2016_12 . . 1 17
23 Aalborg University Hosp Denmark 2014_08 2016_10 1 . . 17
24 Royal Derby Hosp UK 2010_07 2016_09 . . . 17
25 London, St Bartholomews Hosp UK 2010_11 2016_06 . . . 17
26 Newcastle, Freeman Hosp UK 2010_07 2016_01 . . . 17
27 Northampton Gen Hosp UK 2010_05 2016_12 . . 1 16
28 Rhyl, Glan Clwyd UK 2009_05 2016_12 1 . 2 16
29 Sherbrooke, Centre Hosp Uni Canada 2011_06 2016_06 . . . 16
30 Manchester, Christie Hosp UK 2008_06 2016_09 . . . 15
31 Somerset, Musgrove Park hosp UK 2010_11 2016_05 . . . 15
32 Manchester, Hope Hosp UK 2009_05 2014_11 . . . 15
33 Royal Shrewsbury Hosp UK 2012_07 2016_11 . 1 . 14
34 Cardiff, Uni Hosp of Wales UK 2008_09 2016_03 . . . 14
35 Southend Hosp UK 2009_07 2015_10 . . . 13
36 Manchester, Stepping Hill Hosp UK 2009_06 2016_09 . . . 12
37 Galway Uni College Hosp Ireland 2011_06 2013_08 . . . 12
38 Cheltenham Gen Hosp UK 2011_08 2016_09 . . . 11
39 Doncaster Royal Inf UK 2011_06 2016_04 . . . 11
40 Royal Preston Hosp UK 2011_01 2016_03 . . . 11
41 Royal Blackburn Hosp UK 2010_12 2015_12 . . . 11
42 Bristol Haem & Onco Centre UK 2009_11 2013_01 . . . 11
43 Bath, Royal United Hosp UK 2011_06 2016_12 . 1 3 10
44 Portsmouth, Queen Alexandra Hosp UK 2010_03 2016_12 . . 1 10
45 London, St. George's Hosp UK 2011_07 2016_10 1 . . 10
46 Salisbury Dist Hosp UK 2010_09 2016_06 . . . 10
47 Nottingham Uni Hosp UK 2009_01 2016_03 . . . 10
48 Swansea, Singleton Hosp UK 2012_11 2015_12 . . . 10
49 Lincoln County Hosp UK 2008_08 2016_12 . . 1 9
50 Poole Hospital UK 2010_06 2016_07 . . . 9
51 Birmingham, Good Hope Hosp UK 2011_09 2016_06 . . . 9
52 Worchestershire Royal Hosp UK 2011_12 2015_10 . . . 9
53 Wirral, Clatterbridge Centre For Onc UK 2010_03 2016_06 . . . 8
54 Leicester Royal Infirmary UK 2013_01 2016_02 . . . 8
55 Sutton, Royal Marsden Hosp UK 2007_11 2015_01 . . . 8
56 London, Whipps Cross Uni Hosp UK 2012_02 2014_08 . . . 8
57 London, Mayday Hosp UK 2008_03 2014_06 . . . 8
58 Slough, Wexham Park Hosp UK 2010_12 2013_07 . . . 8
59 Weston Park Hosp UK 2010_11 2016_11 . 1 . 7
60 Colchester, Essex County Hospital UK 2012_11 2016_09 . . . 7
61 Redditch, Alexandra Hosp UK 2012_03 2016_05 . . . 7
62 Swindon, Great Western Hosp UK 2010_09 2015_03 . . . 7
63 Toronto, Princess Margaret Hosp Canada 2008_07 2013_06 . . . 7
64 Bournemouth,Royal Bournemouth Hosp UK 2011_02 2016_11 1 1 . 6
65 Bangor, Ysbyty Gwynedd UK 2013_01 2016_08 . . . 6
66 Oxford, Churchill Hosp UK 2011_06 2016_07 . . . 6
67 Aarhus University Hosp Denmark 2012_08 2016_02 . . . 6
68 Kidderminster Hosp UK 2012_07 2016_02 . . . 6
69 Odette Cancer Centre Canada 2011_11 2016_01 . . . 6
70 Edinburgh, Westen Gen UK 2009_06 2015_06 . . . 6
71 Crewe, Leighton Hosp UK 2010_12 2014_09 . . . 6
72 London, Royal Marsden Hosp UK 2010_04 2013_08 . . . 6
73 Forth Valley Royal Hosp UK 2011_05 2016_12 . . 1 5
74 Hereford County Hospital UK 2012_05 2016_12 . . 1 5
75 Grand River Regional Cancer Centre Canada 2012_12 2016_10 1 . . 5
76 Ayr Hosp UK 2009_12 2016_05 . . . 5
77 Stoke, Uni Hospital Of North Staffordshire UK 2015_08 2015_11 . . . 5
78 Torbay District Gen Hosp UK 2011_05 2015_06 . . . 5
79 Scunthorpe Gen Hosp UK 2010_11 2016_12 . . 1 4
80 Centre Hosp. Regional Trois-Rivieries Canada 2013_10 2016_08 . . . 4
81 Sutton-In-Ashfield, King's Mill Hosp UK 2012_06 2016_01 . . . 4
82 Cornwall, Royal Cornwall Hosp UK 2013_08 2016_09 . . . 3
83 London, Charing Cross Hosp UK 2010_05 2016_08 . . . 3
84 Dorset County Hosp UK 2009_09 2016_05 . . . 3
85 London, Royal Free UK 2010_08 2016_01 . . . 3
86 Chesterfield Royal Hosp UK 2011_01 2015_06 . . . 3
87 Ottawa Health Research Inst Canada 2012_02 2015_05 . . . 3
88 Royal Sussex C Hosp UK 2012_11 2015_04 . . . 3
89 Worthing Hosp UK 2011_10 2015_04 . . . 3
90 Middlesbrough James Cook Univ Hosp UK 2009_03 2014_07 . . . 3
91 London, Regional Cancer Program Canada 2011_03 2011_07 . . . 3
92 Cambridge Addenbrooke's Hosp UK 2008_02 2011_02 . . . 3
93 Manchester, Withington Hosp UK 2010_09 2011_01 . . . 3
94 Basingstoke & N Hampshire Hosp UK 2015_11 2016_02 . . . 2
95 Eastbourne District General Hosp UK 2012_01 2015_09 . . . 2
96 Inverness, Raigmore Hosp UK 2012_09 2015_06 . . . 2
97 Aberdeen Royal Inf UK 2012_06 2014_11 . . . 2
98 Edinburgh, Weston Gen Hosp UK 2010_12 2014_10 . . . 2
99 Peterborough District Hosp UK 2012_10 2014_06 . . . 2
100 Yeovil District Hosp UK 2013_12 2014_06 . . . 2
101 London, St Mary's Hosp UK 2011_02 2012_06 . . . 2
102 Vancouver Cancer Centre Canada 2009_06 2011_09 . . . 2
103 Halifax NS, Q Elizabeth II Health Centre Canada 2010_03 2010_10 . . . 2
104 Glasgow, W Scotland Cancer Centre UK 2009_05 2009_11 . . . 2
105 Ipswich Hosp UK 2016_12 2016_12 . . 1 1
106 Harlow, Princess Alexandra Hosp UK 2016_09 2016_09 . . . 1
107 North Devon District Hosp UK 2016_07 2016_07 . . . 1
108 Wrexham Maelor Hosp UK 2016_07 2016_07 . . . 1
109 Western Manitoba Cancer Centre UK 2016_02 2016_02 . . . 1
110 Norfolk and Norwich University Hosp UK 2015_03 2015_03 . . . 1
111 Royal Liverpool Uni Hosp UK 2013_08 2013_08 . . . 1
112 Kelowna, Bc Cancer Cent-Southern Interior Canada 2012_11 2012_11 . . . 1
113 Chelmsford, Broomfield Hosp UK 2011_03 2011_03 . . . 1
114 Chester, Countess of Chester UK 2010_12 2010_12 . . . 1
115 Reading, Royal Berkshire Hosp UK 2010_12 2010_12 . . . 1
116 London, Hammersmith UK 2010_10 2010_10 . . . 1
117 Airedale Gen Hosp UK 2010_09 2010_09 . . . 1

Table 4 - Characteristics at randomisation

Variable Allocated treatment - RADICALS-RT
Early RT Deferred RT
Planned RT schedule 1 52.5Gy in 20 fractions 215 (33%) 214 (33%)
66Gy in 33 fractions 423 (65%) 424 (65%)
Other (discuss with MRC CTU or NCIC CTG) 12 (2%) 11 (2%)
Planned RT target 1 Prostate bed 615 (95%) 626 (96%)
Prostate bed and pelvic lymph nodes 34 (5%) 23 (4%)
Choice of hormone therapy of allocated 1 LHRH agonist with short course anti-androgen 115 (68%) 108 (70%)
Bicalutamide monotherapy 150 mg/daily 55 (32%) 44 (28%)
LHRH antagonist 0 (0%) 3 (2%)
Age at randomisation 2 65 (9) [643] 65 (9) [642]
1: n (column percentage) 
2: Median (IQR) [n] 

Table 5 - Baseline characteristics

Variable Allocated treatment - RADICALS-RT
Early RT Deferred RT
Gleason score 1 <7 49 (8%) 47 (7%)
=7 497 (77%) 492 (76%)
>7 103 (16%) 109 (17%)
Extraprostatic extension 1 Absent 188 (29%) 193 (30%)
Present 442 (68%) 433 (67%)
Not known 18 (3%) 20 (3%)
Positive margins 1 Absent 238 (37%) 239 (37%)
Present 411 (63%) 409 (63%)
Seminal Vesicle involvement? 1 Absent 523 (81%) 510 (79%)
Present 117 (18%) 121 (19%)
Not known 9 (1%) 16 (2%)
Radical prostatectomy technique 1 Open retropubic 188 (29%) 192 (30%)
Open Perineal 10 (2%) 6 (1%)
Laparoscopic 147 (23%) 122 (19%)
Robotic 263 (41%) 279 (43%)
Not known 38 (6%) 46 (7%)
Node dissection performed? 1 No 299 (46%) 277 (43%)
Yes, nodes negative 313 (48%) 344 (53%)
Yes, nodes positive 36 (6%) 25 (4%)
Charlson comorbidity index 1 0 536 (83%) 529 (82%)
1 81 (13%) 91 (14%)
2 18 (3%) 21 (3%)
3 9 (1%) 5 (1%)
4 3 (0%) 0 (0%)
7 1 (0%) 1 (0%)
1: n (column percentage) 

Note: data only available for patients who have returned a baseline form


Sitemap | Accessibility | Webmaster

©2015 RADICALS, MRC CTU at UCL