MRC Clinical Trials Unit at UCL
Institute of Clinical Trials & Methodology
90 High Holborn
2nd Floor
London
WC1V 6LJ
Email. mrcctu.radicals@ucl.ac.uk
In the UK, radiotherapy is usually given after surgery only to those men who have a rising PSA level some time after surgery (known as deferred radiotherapy).
An alternative approach is to use radiotherapy routinely in all men shortly after surgery (known as early radiotherapy or adjuvant radiotherapy). Early radiotherapy might prevent the cancer from coming back but it might also bring unwanted side-effects.
The Radiotherapy Timing Comparison in RADICALS is comparing these two approaches. Men are divided at random into two groups:
This will test whether using radiotherapy routinely soon after surgery is better than giving it later only to those men who develop a rising PSA level.
This is the design of the Radiotherapy Timing Comparison:
RADICALS
MRC Clinical Trials Unit at UCL
Institute of Clinical Trials & Methodology
90 High Holborn
2nd Floor
London
WC1V 6LJ
Email. mrcctu.radicals@ucl.ac.uk